Localization & Plasticity

Localization of function is the theory that specific parts of the brain are responsible for specific behaviours or cognitive processes. The case study of HM is a good example of how a specific part of the brain has a specific function – that is, the hippocampus is responsible for transferring short-term memory to long-term memory.  Although we know that some parts of the brain do play specific roles in behaviour, rarely does a part of the brain work in complete isolation. For example, in memory research, we argue that the cognitive process is the result of distributive processing rather than localization of function – in other words, several parts of the brain have to work together in order to help us create and retrieve memories. Today researchers continue to attempt to map the brain.  One of the ways that they are doing this is by looking at the neural connections in the brain and creating a map called a connectome.  

ATL: Inquiry

Star Trek episodes used to begin with the line, “Space – the final frontier!”  But perhaps there is a frontier much closer to home – the human brain.  One of the great challenges of the 21st century is to create a map of the brain that identifies the neural pathways of the brain and how they interact.

Go to the website for the “Human Connectome Project.”  What do the researchers hope that this project will achieve?  Why might this project be as “exciting” as the website claims?

When talking about the brain, we discuss four key areas: the brain stem, the cerebellum, the cerebrum, and the limbic system.

The brain stem is not usually studied by psychologists.  The brain stem is responsible for regulating life functions, such as breathing, heart rate and blood pressure. The cerebellum plays a key role in balance and motor function, including speech production.  It also plays a role in learning – specifically, in classically conditioned responses.

The cerebral cortex is the largest part of the human brain, associated with higher brain function such as thought and action. The cerebrum is divided into four sections, called lobes

Each of these lobes plays a key role in behaviour:

·      The Frontal Lobe is associated with executive functions – that is, planning, decision making and speech.

·      The Occipital Lobe is associated with visual processing.

·      The Parietal Lobe is associated with perception of stimuli;

·      The Temporal Lobe is associated with auditory processing and memory.

The Limbic System - often referred to as the emotional brain - is a major focus of psychological research for its role in memory and emotion.  In the table below, you will find the key components of the limbic system.

The Limbic System

AmygdalaPlays a role in the formation of emotional memory and fear responses.
Basal gangliaPlays a role in habit-forming and procedural memory.
HippocampusResponsible for transfer of short-term memory to long-term memory
HypothalamusInvolved in homeostasis, emotion, thirst, hunger, circadian rhythms and control of the autonomic nervous system. In addition, it controls the pituitary gland.
Nucleus accumbensPlays a role in addiction and motivation.

ATL: Communication

Choose one of the areas of the brain mentioned in this section and do a bit of research. Create a simple graphic that shows how the lobe or structure plays a role in human behaviour.

In the previous section, we looked at the case study of HM.  Researchers were able to determine through their long-term study of HM that the hippocampus plays a key role in the transfer of information from short-term memory to long-term memory. A review of the study can be seen in the following video.

But as you can see, there the answer to the question of how memory works was not complete from the study of HM.  Other studies have shown us more about how memory works, including the case study of Eugene Pauly.

Research in psychology: The case of Eugene Pauly

In 1992 Larry Squire and his team were introduced to one of the most interesting cases of amnesia since the famous HM study.  At the age of 70, Eugene Pauly was diagnosed with viral encephalitis. Both his amygdala and hippocampus were completely destroyed.  He demonstrated many of the same symptoms as HM.

Squire carried out a series of interviews with EP at his home. During one interview he asked EP to draw a map of his home.  He was not able to do it. However, EP excused himself and got up to go to the toilet. How could a man that could not draw a map of his home find the bathroom on his own?

Several tasks which we do which rely on procedural memories make this transition from involving an active frontal lobe to simply an active basal ganglia. Although the actual process is complex and not fully understood, when we are learning to do a task it is often cognitive in nature. So, when I first learn to drive a car, I need to think an awful lot about what I am doing. But remember, thinking takes up a lot of energy.  Our brains have adapted in a way that minimizes the amount of energy that it needs to expend.  Over time, the task is no longer cognitive, but what is referred to as an associative task. But chunking together a series of movements or behaviours, the task becomes automatic.  The more common word we use for associative tasks is "habits."

EP was also able to take a walk around the block by himself. His wife would even follow him around the block to make sure that he was ok, but he was able to find his way home without any problems. When he was asked from any point on his walk where he lived, he would say he didn't know, but since the task was associative - or a habit - he was able to simply walk home. However, occasionally there was a problem.  If the sidewalk was being repaired and he had to leave his familiar path, EP would get lost.  Returning to our example of driving a car - even when we drive a long time, bad weather or heavy traffic forces us to concentrate more. The task reverts from associative to cognitive.  When this happened to EP, he did not have the capacity to solve the problem as his memory was only procedural. Once the familiar pattern was changed, he was unable to complete the task.

In this case study, Squire & his team carried out several different research methods including interviews with EP and his family, psychometric testing (IQ testing), and observational studies.  In addition, MRIs were used to determine the extent of the damage to EP's brain. MRI indicated that EP's basal ganglia were undamaged.  It is believed that the basal ganglia are responsible for this type of procedural memory.

Click here for a complete description of the Case of Eugene Pauly.

Brain plasticity

The brain is a dynamic system that interacts with the environment. In a sense, the brain is physically sculpted by experience. Not only can the brain determine and change behaviour, but behaviour and environment can change the brain. Modern researchers argue that the brain is constantly changing as a result of experience throughout the lifespan.

Plasticity refers to the brain’s ability to alter its own structure following changes within the body or in the external environment.

Brain plasticity refers to the brain’s ability to rearrange the connections between its neurons - that is, the changes that occur in the structure of the brain as a result of learning or experience. High levels of stimulation and numerous learning opportunities lead to an increase in the density of neural connections. This means that the brain of an expert musician should have a thicker area in the cortex related to mastery of music, when compared to the brain of a non-musician. The same can be said about students who spend a lot of time studying, compared to students who do not. Every time we learn something new, the neurons connect to create a new trace in the brain. This is called dendritic branching because the dendrites of the neurons grow in numbers and connect with other neurons.

This can be illustrated by a series of studies of brain plasticity carried out by Rosenzweig, Bennett and Diamond (1972). The researchers conducted experiments where they placed rats into one of two environments to measure the effect of either enrichment or deprivation on the development of neurons in the cerebral cortex. In the enriched environment, rats were placed in cages with up to 11 other rats. In addition, there were stimulus objects for the rats to play with, as well as maze training.  In the deprived environment, the rat was alone with no stimulation. The rats spent 30 or 60 days in their respective environments and then they were killed in order to measure the effect of the environment on their brain structures.

Post-mortem studies of their brains showed that those that had been in the stimulating environment had an increased thickness in the cortex as a result of increased dendritic branching compared to the rats in the deprived environment. The frontal lobe, which in humans is associated with thinking, planning, and decision making, was heavier in the rats that had been in the stimulating environment. The combination of having company and many interesting toys created the best conditions for developing cerebral thickness.

This raises the question of the importance of stimulation and education in the growth of new synapses. If learning always results in an increase of dendritic branching, then the findings from animal studies that show increased dendritic branching in response to environmental stimulation are important for the human cortex as well. This was seen in a key study done by Maguire et al (2000).  Unfortunately, environmental stressors can also have a negative effect on brain structures.  Carrion et al (2009) found that children who had been abused tend to show a smaller hippocampus than their same-age peers.

Research in psychology: Maguire et al (2000)

The aim of the study was to see whether the brains of London taxi drivers would be somehow different as a result of the exceptional training that they have to do to be certified. All potential taxi drivers must learn “the Knowledge” – that is, they must form a mental map of the city of London.

The participants for this quasi-experiment were 16 right-handed male London taxi drivers. The brain of the taxi drivers were MRI scanned and compared with the MRI scans of 50 right-handed males who did not drive taxis (the control group). In order to take part in the study, the participants had to have completed the "Knowledge" test and have their license for at least 1.5 years. The controls were taken from an MRI database. The sample included a range of ages so that age would not be a confounding variable.

The study is correlational as the IV was not manipulated by the researcher but naturally occurring. The researchers were looking to see if there was a relationship between the number of years of driving a taxi and the anatomy of one's brain. It was also a single-blind study - that is, the researcher did not know whether she was looking at the scan of a taxi driver or a control.

There were two key findings of the study. First, the posterior hippocampi of taxi drivers were significantly larger relative to those of control subjects and the anterior hippocampi were significantly smaller.  Secondly, the volume of the right posterior hippocampi correlated with the amount of time spent as a taxi driver. No differences were observed in other parts of the brain. Maguire argues that this demonstrates that the hippocampus may change in response to environmental demands.

The study of localization of function and brain plasticity are very much linked.  Studies from both abnormal and developmental psychology have demonstrated, for example, the way that stress has an effect on memory by interfering with the work of the hippocampus.  In addition, long-term stress appears to lead to hippocampal atrophy - that is, hippocampal cell death that leads to a smaller hippocampus.  This was found in a study by Bremner (2003).

Thirty-three women participated in this study, including women with early childhood sexual abuse and PTSD (N=10), women with abuse without PTSD (N=12), and women without abuse or PTSD (N=11). The researchers used an MRI to measure the volume of the hippocampus in all of the participants - and a PET scan to measure its level of function during a verbal declarative memory test.  Women that were abused and showed symptoms of PTSD were foud to have 16% smaller volume of the hippocampus compared to women with abuse without PTSD. In addition, these women showed a lack of activity in the hippocampus when carrying out the memory task.  Women with abuse and PTSD had a 19% smaller hippocampal volume relative to women without abuse or PTSD.

Exam preparation: Linking to curriculum

When discussing localization of brain function and neuroplasticity, there are several other examples throughout the course which you may choose to use.  Here are some examples.

  • Localization of function:  the case of HM and the hippocampus
  • Localization of function: the case of Eugene Pauly and the basal ganglia
  • Localization of function:  the role of the amygdala in flashbulb memory.
  • Localization of function: the role of the ventromedial prefrontal cortex in decision making

Checking for understanding

Which of the following in an example of localization of function?

When more than one part of the brain is involved, this is a distributive function.  The brain changing in reaction to the environment is known as neuroplasticity.  The different hemispheres of the brain do help the opposite side of the body; this is called in lateralization, not localization.

 

Which lobe is responsible for processing visual information?

 

 

Which of the following might be a symptom of damage to the frontal lobe?

 

 

If there was damage to the amygdala, which symptom might we observe?

 

 

Which part of the neuron is most affected by learning?

Neuoplasticity is the result of "dendritic branching" - and this is what happens when we learn though interacting with our environment.

 

Which of the following is not true of Rosenzweig, Bennett & Diamond's (1972) study?

The study does not do a good job of isolating variables.  It is unclear if it was the visual stimulation, the social interaction with other rats or the exercise provided by a track wheel that led to the denser frontal lobe in the rats.

 

According to Carrion (2009), what effect can stress in the environment have on the brain of children?

Stress hormones lead to hippocampal cell death. This has an effect on the ability of children to form long-term memories, and thus is a sign of cognitive impairment.

 

What research method did Maguire use for her study of brain plasticity in taxi drivers?

There was no manipulation of the IV.  The length of time that they were driving a taxi was not manipulated by the researcher and they could not be randomly allocated to groups.  Since the could not be any demand characteristics from the participants as they could not change the structure of their brains, the study does not need any deception.  However, in order to prevent researcher bias in interpreting the structure of the brain, the researchers were unaware of which brain they were examining.  This means it is a single-blind control.

 

Total Score:

Neurotransmission  

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Comments 12

Megan Fallon 6 March 2018 - 01:14

Hi John so with Bremner we are saying PTSD causes the breaking of synaptic connections in the hippocampus and this is how it illustrates neuroplasticity ?

John Crane 6 March 2018 - 21:43

Dear Megan,

Yes. Part of the definition is that synapses can strengthen or weaken. Research also shows that neurogenesis in the hippocampus may also lead to the extinction of some PTSD fear responses. elifesciences.org

Virginia Shrader 18 April 2018 - 02:22

Plasticity refers to the brain’s ability to its own structure following changes within the body or in the external environment. To alter, reorganize, adapt, reform?

John Crane 18 April 2018 - 06:55

Virginia

I don’t understand your question.

Ian Latham 31 July 2018 - 17:26

The elifesciences.org link is interesting. Thanks! In the introduction the authors state "Increasing hippocampal neurogenesis following training accelerated forgetting, whereas reducing hippocampal neurogenesis following training stabilized or strengthened existing hippocampus-dependent memories". The authors write in the context of PTSD, but could this also tie in with (low) neurogenesis in cases of depression? The idea that SSRIs contribute to neurogenesis could be due to them interferring with establishing and reconsolidating negative 'connections' (call them memories, beliefs or thoughts), allowing new alternative connections. What about the idea that (negative) rumination reduces opportunities for neurogenesis due to time & energy spent on strengthening existing negative 'connections'?

John Crane 2 August 2018 - 07:33

Dear Ian

Yes, I think that it fits perfectly with depression as well. I also talk about SSRIs in this context with students, but have never thought about rumination. It is something for me to investigate. Do you have anything on that theory?

Ian Latham 2 August 2018 - 17:36

Buried in an article on different types of rumination by Hoeksema I believe. When I get round to going through things with a finer tooth comb, I'll look for it. I've got about 72 hrs left to reorganise files and objectives for the new intake and then I'm off for a month! Hope you had a great time :-)

John Crane 3 August 2018 - 05:19

Thanks, Ian. Enjoy your month off! I start work on the 13th, my 30th anniversary of my arrival here in the Czech Republic (will always be Czechoslovakia to me).

Tripti Rathore 21 August 2018 - 06:51

Dear John,
For the answer on Neuroplasticity is it advisable to refer to Rosenzweig and Bennet

John Crane 22 August 2018 - 05:10

Dear Tripti

The IB has said that on Paper 1, students must use human examples. HL students may use Rosenzweig and Bennet for the animal research essay. Theoretically, students may use the study for neuroplasticity if they can explicitly "link it to human behaviour," but it would be wiser to use a study like Maguire.

Tripti Rathore 24 August 2018 - 06:53

Thanks a ton but if they ask ERQ on Neuroplasticity then another study could be case study of HM

John Crane 25 August 2018 - 06:05

Tripti,

I am not sure how HM could be a study of neuroplasticity - it was not what was studied in that study. I think that if a student used it for an SAQ it would likely not get much credit.